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Base editing doubles lifespan...!! (in progeria mouse model)

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Base editing is back. Here we look at how base editing was employed in a recent study to repair the genetic mutation that causes Hutchinson-Gilford progeria syndrome (progeria) in a mouse model. Progeria causes accelerated aging and patients with this disease typically die around the age of 14 or 15 years. Remarkably, with a single AAV injection of an adenine base editor and a gRNA targeting the Lamin A gene (LMNA) that is mutated in progeria, the median lifespan on the mice were more than doubled!

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TIMESTAMPS;
Intro - 00:00
What causes progeria? - 00:40
What is base editing? - 06:15
Study results - 08:10
Thoughts, further q's - 13:12
Outro - 14:10

References;
Koblan, L.W., Erdos, M.R., Wilson, C. et al. In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice. Nature (2021). https://doi.org/10.1038/s41586-020-03086-7
Nature news & views - https://www.nature.com/articles/d41586-020-03573-x

Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com
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